Andrology Laboratory Services
Diagnosis of male fertility often starts with Semen Analysis (SA) which is based on sperm motility and macroscopic evaluation. often basic Semen Analysis (SA) may not accurately reflect for fertilization ability of the sperm. This is when more comprehensive sperm function tests should be performed.
Andrology Laboratory (SAL) is a one-stop centre offers a full spectrum of highly personalised care, support and fertility treatment options encompassing the following:
- Investigations of male and female infertility with graduated treatment options such as Intrauterine Insemination (IUI), In-vitro Fertilization (IVF) Intracytoplasmic Sperm Injection (ICSI, frozen-thawed embryo transfers, assisted hatching, blastocyst culture and in-vitro egg maturation.
- Andrology services to help azoospermic males including Microsurgical Epididymal Sperm Aspiration and Testicular Sperm Extraction.
- Supporting all gynaecologists which include semen analysis, sperm preparation for IUI and sperm banking for husbands of patients.
- Andrology services include sperm preparation for IUI, sperm freezing and storage for husbands who are not available during treatment or husbands with sperm retrieved from Epididymis or testis or for men with cancer before cancer treatment. Our dedicated diagnostic laboratory provides services on semen analysis and related tests.
We are Singapore first and only Andrology Laboratoary focused on Oxidative Stress Assay (OSA), as they are are not commonly done in other laboratory. Due the less demand in the market, most laboratory do not perform such functional test.
The Sperm Chromatin Dispersion (SCD) test, which is a simple, fast, and reliable procedure, is used to determine the frequency of sperm cells with fragmented DNA. The frequency of sperm DNA fragmentation is expressed as DNA Fragmentation Index (DFI). A sample with DFI <10% has high fertilization potential while a DFI >30% denotes poor prognosis for IUI and IVF treatment and the man will require clinical treatment to improve his sperm quality.
It is possible that excessive reactive oxygen species (ROS) generation by the human spermatozoa contributes to the aetiology of the male infertility. The result of such an oxidative stress is the induction of lipid per oxidation in the sperm plasma membrane, suppression of the sperm functions, and the precipitation of the DNA damage to both the nuclear and the mitochondrial genomes.
Sincere Andrology Laboratory can perform an assay that is reliable and sensitive to measure a possible excess of superoxide anions present in the ejaculate.
Many retrograde ejaculation patients will have had prior surgery or a medical condition that predisposes them to retrograde ejaculation, such as testicular cancer surgery (RPLND), transurethral surgery of the prostate, or childhood bladder surgery etc. Medical conditions such as diabetes, MS, or spinal cord injury may also predispose an individual to retrograde ejaculation.
● Trial Wash